FIGURE 2.

Pharmacologic inhibition of SHP2 relieves T-cell exhaustion and reprograms the tumor–immune microenvironment. A, Quantification of CD4⁺ population as a frequency of CD45⁺ cells in isolated spleens (left) and lung tissues (right) of each group. B, Quantification of TIM3⁺LAG3⁺ population as a frequency of CD45⁺CD4⁺ cells in isolated spleens (left) and lung tissues (right) of each group. C, Quantification of TIM3⁺LAG3⁺ population as a frequency of CD45⁺CD8⁺ cells (left) and CD45⁺CD8⁺PD-1⁺ cells (right) of in isolated lung tissues of each group. D, Quantification of F4/80⁺ population as a frequency of CD45⁺CD11b⁺ cells in isolated lung tissues of each group. E, Plots comparing the ratio of CD86⁺ and CD206⁺ in F4/80⁺ population as M1/M2 in isolated lung tissues of each group. F, Quantification of PD-L1⁺ population as a frequency of CD45⁻ cells in isolated lung tissues of each group. In all panels. *, P < 0.05; **, P < 0.01; ***, P < 0.001; n = 3.