FIGURE 8.

Tumor cell–autonomous SHP2 is a key signaling node in response to dynamic TME to induce immune suppression via regulating PD-L1 and MHC class I. SHP2 contributes to various downstream signaling pathways including PD-L1 and MHC class I to facilitate immune suppression in response to a varieties of additional signaling inputs in TME, such as growth factor receptor signaling. Figure was created using BioRender.