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PTBP1-dependent regulation of TP63γ in HNSCC. Graphical abstract of the main conclusion and hypothesis. Left side, PTBP1 by binding on 3′SS and CPA of the alternative terminal exon γ repress its inclusion in the mature RNA. Right side, upon decreased PTBP1 expression, accumulation of TP63γ promotes formation of TP63 α/γ heterotetramers that repress desmosomal genes expression in primary tumors, alter epithelial characteristics, and promote an unfavorable prognostic.
