Table 1. Main characteristics of Candida auris clades.

Characteristics	Clades
	South Asian (I)	East Asian (II)	African (III)	South American (IV)	Iranian (V)
Antifungal susceptibility profile	Resistant to FLU, cross-resistant to echinocandins and AMB, some are pan-resistant	Lower resistance to antifungal agents	Resistant to FLU, cross-resistant to echinocandins and AMB, some are pan-resistant	Resistant to FLU, cross-resistant to echinocandins and AMB, some are pan-resistant	Resistant to FLU, cross-resistant to echinocandins and AMB, some are pan-resistant
Clinical isolation site	Ear, blood, or other invasive sites	Mainly ear	Ear, urine, blood, or other invasive sites	Blood, or other invasive sites	Nail, skin, ear
Mating type	MTLa	MTLα	MTLα	MTLa	Not known
ERG11 mutations	Y132F or K143F	K143R, L43H, Q357K	F126L	Y132F, K143R, K177R, N335S, E343D	Y132F, I466L
TAC1B mutations	R495G, A640V, A657V, A15T, S195C, P595L	F214S	None	F214S, F862_N866del, K247E, M653V, A651T, P595H	Not known
Outbreaks	Invasive infections	Ear infections	Invasive infections	Invasive infections	Invasive infections
Geography	Dominates in the United States, Europe, South Asia	Dominates in Korea, Japan	Dominates in Europe, Africa	Dominates in the United States	Dominates in Iran
Phenotypes
Growth on actidione	No	Yes	Yes	Not known	Not known
Pseudohyphae	Yes	No	No	Not known	Not known
Large cellular aggregates	No	Yes	Yes	Not known	Not known
Assimilation of L-rhamnose	No	No	Yes	No	Yes
Utilization of N-acetyl glucosamine	Yes	No	Yes	Yes	Yes

AMB, amphotericin B; del, deletion; FLU, fluconazole.

Data obtained from references [4,13,24,25,28–30].