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. 2023 Mar 23;18(3):e0283459. doi: 10.1371/journal.pone.0283459

Table 2. Regression analysis for factors associated with PE in ED patients with COVID-19.

Univariate analysis Multivariate analysis
Variables OR 95% CI P-value OR 95% CI P-value
Age per 5 years 1.08 0.96–1.21 0.20
Male sex 1.01 0.54–1.88 0.97
BMI (kg/m 2 )
 <25 Reference
 25–30 1.06 0.51–2.18 0.88
 ≥30 0.69 0.30–1.59 0.38
Chronic comorbidity
 COPD 0.84 0.35–2.05 0.71
 Malignant neoplasms 2.29 0.84–6.28 0.11 2.54 0.83–7.73 0.10
 CCI ≥4 1.55 0.84–2.84 0.16
Vital signs
 Heart rate >100 bpm 1.73 0.94–3.19 0.08 1.37 0.67–2.78 0.39
 Temperature ≥38.5°C 0.56 0.27–1.16 0.12
Laboratory results
 D-dimer per 1000 μg/L 1.10 1.07–1.13 <0.001 1.09 1.06–1.13 <0.001
 CRP >100 mg/L 2.61 1.42–4.81 0.002 2.78 1.37–5.66 0.005
 Ferritin >900 μg/L 1.66 0.91–3.02 0.10
 Lactate >1.8 mmol/L 2.44 1.30–4.57 0.006 1.77 0.89–3.54 0.11

BMI, body mass index; bpm, beats per minute; CCI, Charlson Comorbidity Index; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; OR, Odds ratio.

Other variables listed in Table 1 but not shown here were not associated with PE in univariate analysis.