Table I.
Patient characteristics
| Characteristic | Value |
|---|---|
| Demographics | |
| M/F | 8/61 |
| Mean age (range) (y) | 52 (18-86) |
| Relevant clinical history (n = 69) | |
| Asthma | 7 |
| Chronic urticaria | 3 |
| Inhalation allergy | 4 |
| Reason for referral (n = 69), n (%) | |
| Anxiety | 23 (33) |
| Multiple anaphylaxis | 1 (1) |
| Refused by vaccination center | 4 |
| Suspected hypersensitivity to unrelated drugs | 1/4 |
| Suspected hypersensitivity to macrogol | 1/4 |
| Anaphylaxis to diclofenac (which contains tromethamine) in clinical history | 1/4 |
| Possibly angioedema after unknown vaccine, more than 10 years ago | 1/4 |
| Symptoms after first or second dose∗ (n = 41), n (%) | |
| Immediate (pre)syncope, hypotension, palpitations | 14 (34) |
| Immediate dyspnea | 8 (20) |
| Immediate dysphagia | 2 (5) |
| Immediate hoarseness | 1 (2) |
| Immediate nausea | 2 (5) |
| Immediate headache | 2 (5) |
| Immediate pruritus | 7 (17) |
| Immediate flushing | 1 (2) |
| Immediate urticaria | 4 (8) |
| Immediate angioedema/sensation of swelling | 12 (29) |
| Urticaria >1 day after vaccination | 2 (5) |
| Unspecified skin rash | 4 (8) |
| Angioedema/sensation of swelling >1 day after vaccination | 2 (5) |
∗
Seventeen patients showed signs and symptoms compatible with an immediate hypersensitivity reaction after administration of the vaccine.