Table 4.
Plasma TTV cut-off values at the time of first vaccination (T0) for the prediction of seroconversion after two-dose vaccination (T1).
| Copies/ml TTV | Sensitivity% (95% CI) | Specificity% (95% CI) | PPV% (95% CI) | NPV% (95% CI) |
| < 103 | 6.5 (1.2–20.7) | 97.1 (90.0–99.5) | 50.0 (8.9–91.1) | 69.8 (60.0–78.1) |
| < 104 | 25.8 (13.7–43.3) | 75.4 (64.0–84.0) | 32.0 (17.2–51.6) | 69.3 (58.2–78.6) |
| < 105 | 71.0 (53.4–83.9) | 47.8 (36.5–59.4) | 37.9 (26.6–50.8) | 78.6 (64.1–88.3) |
| < 4.0 × 105* | 90.3 (75.1–96.7) | 33.3 (23.4–45.1) | 37.8 (27.7–49.2) | 88.5 (71.0–96.0) |
| < 106 | 93.6 (79.3–98.9) | 21.7 (13.6–32.8) | 34.9 (25.6–45.7) | 88.2 (65.7–97.9) |
| < 107 | 96.7 (83.8–99.8) | 15.9 (9.1–26.3) | 34.1 (25.0–44.5) | 91.7 (64.6–99.6) |
⁎
optimal classifier as determined by Youden's index.