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. 2023 Jan 12;40(3):749–764. doi: 10.1007/s11095-022-03465-x

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Characterization of PLGA-chitosan JNP and JNP-TCZ. (a.1) SEM images of PLGA-chitosan JNP and (b.1) JNP-TCZ; scale bar is 10 μm; insets of intensity-average DLS (a.2, b.2). (c.1–c.4) Key geometric factors of PLGA-chitosan JNP and JNP-TCZ based on SEM analysis (left: half-violin of histogram; right: median as line, box as IQR, and whiskers as 1/99 percentiles). (d.1–d.3) Z-stack projections of SIM micrographs expressing AF488 emission (green), Nile red emission (magenta) and composite images of JNPs; scale bar of 2 μm. (d.4) 3D reconstruction of Z-projection of the JNP oriented to present the compartmental interface; field of view of 2 μm. (e.1) Z-stack intensity profile for both channels and (e.2) intensity profile of the 3D projection as indicated by profile bar in D4. (f) Release kinetics of active TCZ from JNP-TCZ as measured by ELISA (single exponential decay, k = 0.077%/hr).