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. 2023 Jan 12;40(3):749–764. doi: 10.1007/s11095-022-03465-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effects of TCZ releasing JNP on OSCC tumor induction. (a) Gross OSCC tumors at day 27 prior to collection. The tumors treated with JNP-TCZ appeared clinically smaller and less erythematous. (b) At day 27, mice were sacrificed and tumors were excised. The latter were bisected along the greatest dimension plane and histologic size (width x height) was determined for the masses in which tumor islands were still present. The JNP-TCZ tumors were significantly smaller in size and this difference was statistically significant when comparing with JNP-CTR (p < 0.01) and TCZ tumors (p < 0.001). No significant differences were detected in comparison of the JNP-CTR and TCZ tumors. (Not Significant (N.S)).