Table 1.

Results of survival, AUC and NRI analyses for the adult cohort

Variable	Clinical variables (AUC=0.728)			Clinical variables + PS (AUC=0.735)			Clinical variables + 2hPG (AUC=0.760)			Clinical variables + 2hPG + PS (AUC=0.765)
	HR (95% CI)	p value	NRI	HR (95% CI)	p value	NRI	HR (95% CI)	p value	NRI	HR (95% CI)	p value	NRI
Age (decades)	1.01 (0.93, 1.10)	0.869	0.011	1.04 (0.95, 1.13)	0.393	0.067	1.00 (0.92, 1.09)	0.992	−0.045	1.03 (0.94, 1.12)	0.540	0.112
Sex (F/M)	1.35 (1.14, 1.59)	5.48 × 10−4	0.115	1.34 (1.13, 1.58)	7.70 × 10−4	0.116	1.13 (0.953, 1.34)	0.157	0.110	1.13 (0.954, 1.35)	0.154	0.106
Mother diabetic/NonDb	1.52 (1.21, 1.90)	2.75 × 10−4	0.161	1.46 (1.17, 1.83)	2.08 × 10−3	0.140	1.43 (1.14, 1.80)	2.60 × 10−3	0.178	1.38 (1.10, 1.73)	0.0131	0.126
Mother unknown/NonDb	1.45 (1.15, 1.82)			1.38 (1.09, 1.74)			1.39 (1.10, 1.74)			1.33 (1.06, 1.67)
Father diabetic/NonDb	1.45 (1.06, 1.96)			1.38 (1.01, 1.87)			1.38 (1.02, 1.88)			1.33 (0.975, 1.81)
Father unknown/NonDb	1.20 (0.921, 1.56)			1.17 (0.900, 1.52)			1.20 (0.93, 1.56)			1.17 (0.900, 1.52)
BMI (kg/m2)	1.02 (1.01, 1.03)	1.22 × 10−4	0.158	1.03 (1.01, 1.03)	1.03 × 10−5	0.201	1.02 (1.01, 1.03)	2.11 × 10−5	0.242	1.03 (1.02, 1.04)	1.88 × 10−6	0.269
FPG (mmol/l)	1.99 (1.70, 2.33)	2.78 × 10−17	0.303	1.95 (1.66, 2.29)	3.13 × 10−16	0.295	1.44 (1.22, 1.71)	2.51 × 10−4	0.176	1.44 (1.21, 1.71)	2.93 × 10−5	0.191
HbA1c (mmol/mol)	1.08 (106, 1.10)	1.18 × 10−18	0.272	1.08 (1.06, 1.10)	1.14 × 10−17	0.267	1.06 (1.05, 1.08)	9.64 × 10−13	0.215	1.06 (1.04, 1.08)	5.67 × 10−12	0.223
2hPG (mmol/l)	–	–	–	–	–	–	1.32 (1.25, 1.40)	3.74 × 10−24	0.420	1.31 (1.24, 1.38)	6.71 × 10−23	0.426
PS (SD)	–	–	–	1.27 (1.17, 1.38)	1.61 × 10−8	0.270	–	–	–	1.24 (1.15, 1.35)	2.90 × 10−7	0.252

‘Clinical variables’ refers to: age, sex, parental diabetes, BMI and FPG for the adult cohort

NRI is calculated for each predictor by comparing the model including the predictor with a model that does not include the predictor

Db, diabetic with regard to parental diabetes; F, female; M, male