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. 2023 Mar 23;13:4776. doi: 10.1038/s41598-023-31783-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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iDISCO reveals that estradiol reduces c-fos immunoreactivity in brain regions involved in anxiety-like behavior and energy homeostasis in HFD-fed female mice. c-fos immunoreactivity (green) in the (A) paraventricular nucleus of the hypothalamus (PVH), (B) medial preoptic area (MPO), (C) subparafascicular nucleus (SPF) of the thalamus (n = 4/group). Some non-specific c-fos immunoreactivity (red) is also observed. The box limits are the first and third quartiles. The whiskers are at 1.5 times the interquartile range below the first quartile and above the third quartile. *Denotes q < 0.05 between the two groups.