Table 2.

Mediating role of brain age gap in the association between physical puberty age gap and mental health problems.

	Females			Males
	ACME	ADE	Total effect	ACME	ADE	Total effect
Total problem	0.91	< 0.01	< 0.01	0.81	0.99	0.09
Externalising problem	0.45	< 0.01	< 0.01	0.71	0.71	0.20
Internalising Problem	0.84	< 0.01	< 0.01	0.60	0.62	0.20
Withdrawn/Depression	0.09	0.71	0.06	0.76	0.96	0.56
Anxiety/Depression	0.68	0.08	0.08	0.38	0.70	0.42
Somatic Complaint	0.81	< 0.01	< 0.01	0.78	0.59	0.11
Attention problems	0.45	0.61	0.55	0.34	0.77	0.56
Rule breaking	0.46	< 0.01	< 0.01	0.79	0.56	0.08
Aggressive behaviours	0.09	< 0.01	< 0.01	0.54	096	0.59
Thought problems	0.78	0.39	0.36	0.75	0.92	0.27
Social problems	0.73	< 0.01	< 0.01	0.68	0.68	0.09

All p values reported after FDR correction.

ACME = Average Causal Mediation Effect, ADE = Average Direct Effect