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. 2023 Mar 10;14:1139137. doi: 10.3389/fphar.2023.1139137

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Copyright © 2023 Fan, Zhang, Ding, Du, Zhou and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and validation of the biomarkers. (A,B) RF algorithm. (C) SVM-RFE algorithm. (D) LASSO regression analysis. (E) Venn plot exhibiting the reliable biomarkers among LASSO, SVM-RFE, and RF. (F) The visualization of the ANN diagnostic model. (G) The assessment result of the date set. (H) The testification result of the validation set. (I) Validation of the key crosstalk genes in GSE13896. (J) Validation of the key crosstalk genes in GSE130928.