Table 4.
Results of Logistic regression models of the effect of FamRS on risk of prevalent and incident diabetes
| FamRS categories | Outcome: Prevalent T2D | Outcome: Incident T2D | |||||
|---|---|---|---|---|---|---|---|
| OR* | CI (95%) | p-value | OR* | CI (95%) | p-value | ||
| Unadjusted | FamRS 2 | 2.08 | [1.45–2.92] | 4.05 × 10–5 | 1.40 | [0.85–2.19] | 0.165 |
| FamRS 3 | 4.73 | [3.04–7.20] | 1.77 × 10–14 | 3.46 | [1.85–6.09] | 5.89 × 10–5 | |
| Adjusted for Age + Sex + BMI + Physical activity | FamRS 2 | 2.47 | [1.67–3.61] | 4.30 × 10–6 | 1.60 | [0.95–2.58] | 0.062 |
| FamRS 3 | 4.33 | [2.65–6.95] | 2.17 × 10–9 | 3.74 | [1.94–6.82] | 3.49 × 10–5 | |
| Adjusted for Age + Sex + BMI + Physical activity + PGS | FamRS 2 | 1.67 | [1.01–2.71] | 0.041 | 1.45 | [0.86–2.35] | 0.149 |
| FamRS 3 | 2.78 | [1.49–5.09] | 0.001 | 3.47 | [1.79–6.35] | 1.07 × 10–4 | |
*ORs are given for FamRS categories “positive and strong positive family risk” (FamRS 2) and “very strong positive family risk” (FamRS 3) compared to average family risk.