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Model of PKCα regulation of TGFβ signaling. PKCα activation promotes Ras/ERK-dependent phosphorylation/activation of Runx2 to increase TGFβR1 expression and TGFβ-mediated signaling. ERK, extracellular signal-regulated kinase 1/2; PKCα, protein kinase C α; Runx2, runt-related transcription factor 2; TGFβ, transforming growth factor β; TGFβR1, transforming growth factor-β receptor 1.
