Chronic pain is a complex condition with increasing prevalence and significant impact on quality of life for patients necessitating multimodal approaches to pain management.

A variety established and novel invasive and noninvasive approaches besides pharmaceuticals exist for patients suffering from chronic pain.

Options for pharmaceutical adjuncts range from clinic-based interventions to self-administered, noninvasive devices that provide patients with autonomy and control over their chronic pain condition.

The nonpharmaceutical options for treatment of chronic pain continue to grow and evolve with novel technologies and offer patients low-risk alternatives with minimal to no risk for drug–drug interactions.

Despite the promise of these adjuncts to pharmaceutical intervention for chronic pain, a need for large-scale clinical trials and further research remains to elucidate the true efficacy of these interventions.