Figure 1.

Increased level of hepatic p62 and its aggregation in patients with alcoholic hepatitis (AH). (A) Western blot analysis of total liver lysates of healthy donors (normal liver) and AH patients, respectively. LE, long exposure; SE, short exposure. (B) Densitometry analysis of p62 and LC3B expression. Results are presented as mean ± standard error (n = 5–8). ∗P < .05 with Student t test. (C and D) Representative images of H&E and immunohistochemical staining of p62 in liver tissues from AH patients and healthy donors. Arrowheads: hepatocyte ballooning; solid black arrows: lipid droplets; scale bar: 50 μm.