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. 2023 Feb 7;15(5):1027–1049. doi: 10.1016/j.jcmgh.2023.01.016

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

p62 knockout mice develop mature-onset obesity during aging. (A) Representative images of the mice and gross anatomy of livers from young and aged mice with the indicated genotype and treatment. Scale bar: 1 cm. (B) Measurement of mice body weight (in grams). (C) Measurement of liver weight (in grams). (D) Liver to body weight (BW) ratio. (E) Average of food intake (in mL) per day per mouse. (F) Normalized food intake by body weight of the mice in each group. (G) Serum ethanol concentration of young and aged mice with the indicated genotype and treatment. Results are presented as mean ± standard error (n ≥ 4). ∗P < .05; ^#P < .05 between young and aged group; one-way analysis of variance followed by Tukey post hoc test.