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. 2023 Jan 25;15(5):1085–1104. doi: 10.1016/j.jcmgh.2023.01.002

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Myeloid Notch1 deficiency depresses YAP signaling and reprograms macrophage polarization. (A) Flow cytometry analysis of liver macrophages isolated from Notch1^FL/FL and Notch1^M-KO mice (n = 5 mice/group). (B) The Arg1 and iNOS expression were detected by Western blot assay in liver macrophages from Notch1^FL/FL and Notch1^M-KO mice treated with PBS or LPS/D-GalN injection. (C) Quantitative reverse-transcriptase polymerase chain reaction analysis of Yap, Ctgf, and Cyr61 in liver macrophages (n = 5 samples/group). (D) The expression of YAP in liver macrophages from Notch1^M-KO and Notch1^FL/FL mice, as measured by Western blot analysis. (E) The correlation between serum ALT levels and Yap mRNA expression in liver macrophages after LPS/D-GalN injection (n = 15 mice). The correlation coefficient was calculated by the Pearson correlation test. Data are presented as the mean ± standard deviation. ∗P < .05, ∗∗P < .01.