Table 1.

Participant characteristics.

	Variables	N = 24a
Demographics	Age at the time of 11C-PK11195 Scan	78 [64.8, 83]
	Female	14 (58.3%)
	African American	3 (12.5%)
	Education	16 [12 18]
Vascular risk factors	Hypertension	14 (58.3%)
	Hyperlipidemia	12 (50.0%)
	Diabetes Mellitus	3 (12.5%)
	Stroke or transient ischemic attack	2 (8.3%)
	Smoking	1 (4.2%)
	Participants with at least one vascular risk factor	20 (83.3%)
Imaging characteristics	PiB Positive (11C-PiB MCBP > 0.18)	17 (70.8%)
	Baseline WMH volume (ml)	4.06 [2.14, 19.21]
	Baseline normalized WMH volume	0.52% [0.22%, 2.30%]
	Participants with baseline WMH volume >1 ml	17/19 (89.5%)
	WMH volume progression rate (ml per year)b	0.23 [0.12, 0.42]
	Normalized WMH volume progression rate (per year)b	0.03% [0.02%, 0.04%]
	Lacunar infarct	2/21 (9.5%)
	Lobar microbleeds	1/12 (8.3%)
	Deep microbleeds	1/12 (8.3%)
	Cortical superficial siderosis	1/12 (8.3%)
	Enlarged perivascular spaces	9/15 (60%)
Baseline cognitive and functional status	MMSE	28.5 [26.8 30]
	Participants with MMSE ≥ 24	21 (87.5%)
	CDR	0 [0, 0.5]
	Participants with CDR = 0	17 (70.8%)

^aValues are shown as Median [Interquartile range] or numbers (%).

^bN = 9.