Table 3.

Longitudinal prediction of WMH progression using mixed-effects models with a random effect for participant.

Model: WMH volume ∼ Regional 11C-PK11195 SUVR × Age + 11C-PiB MCBP × Age + Sex + Vascular Risk Score
PK Regiona	PK SUVR × Ageb	PiB MCBP × Ageb
Whole Brain ROI	0.030 [0.004, 0.054] *	−0.001 [−0.002, 0.001]
NAWM ROI	0.014 [−0.004, 0.033]	−0.000 [−0.002, 0.001]
WMH ROI	−0.004 [−0.018, 0.010]	−0.001 [−0.003, 0.001]
Cerebral Gray Matter ROI	0.027 [0.010, 0.044] **	−0.000 [−0.002, 0.001]
Precuneus ROI	0.013 [0.002, 0.024] *	−0.001 [−0.003, 0.000]
Posterior Cingulate ROI	0.009 [−0.000, 0.017]	−0.001 [−0.002, 0.001]
Lateral Temporal Cortex ROI	0.012 [−0.002, 0.027]	−0.000 [−0.002, 0.002]
Inferior Parietal Cortex ROI	0.006 [−0.004, 0.016]	−0.001 [−0.003, 0.001]

*P < 0.05.

**P < 0.01.

^aEach row presents results from a separate model evaluating the effect of ¹¹C-PK11195 SUVR in a specific region.

^bValues are shown as beta coefficient [95% confidence internal].