Table 4.

Multiple linear regression models between baseline cognitive function and PET biomarkers.

Model: Baseline zGlobal ∼ Regional 11C-PK11195 SUVR + 11C-PiB MCBP + Age + Education + Vascular Risk Score
PK Regiona	PK SUVRb	PiB MCBPb
Whole Brain ROI	−0.287 [−10.388, 9.813]	−0.568 [−1.032, −0.103]*
NAWM ROI	1.267 [−7.696, 10.231]	−0.589 [−1.050, −0.128]*
WMH ROI
Cerebral Gray Matter ROI
Precuneus ROI
Posterior Cingulate ROI	NAc	−0.569 [−0.993, −0.144]*
Lateral Temporal Cortex ROI
Inferior Parietal Cortex ROI
Model: Baseline zSpeed ∼ Regional 11C-PK11195 SUVR + Age + Education + Vascular Risk Score
PK Regiona	PK SUVRb
Whole Brain ROI	−5.873 [−21.245, 9.499]
NAWM ROI	−3.533 [−17.378, 10.312]
WMH ROI	NAc
Cerebral Gray Matter ROI	−5.351 [−18.828, 8.126]
Precuneus ROI
Posterior Cingulate ROI	NAc
Lateral Temporal Cortex ROI
Inferior Parietal Cortex ROI
Model: Baseline zMemory ∼ Regional 11C-PK11195 SUVR + PiB MCBP + Age
PK Regiona	PK SUVRb	PiB MCBPb
Whole Brain ROI	−5.075 [−16.009, 5.859]	−0.798 [−1.327, −0.268]**
NAWM ROI	−3.550 [−13.990, 6.889]	−0.804 [−1.343, −0.266]**
WMH ROI
Cerebral Gray Matter ROI
Precuneus ROI
Posterior Cingulate ROI	NAc	−0.818 [−1.360, −0.276]**
Lateral Temporal Cortex ROI
Inferior Parietal Cortex ROI

*P < 0.05.

**P < 0.01.

^aEach row presents results from a separate model evaluating the effect of ¹¹C-PK11195 SUVR in a specific.

^bValues are shown as beta coefficient [95% confidence internal].

^cNot included in the multiple linear regression model because P > 0.2 in the univariate test.