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. 2023 Mar 8;220(5):e20221755. doi: 10.1084/jem.20221755

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© 2023 Sharma et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 5. — Primary lymphocytes of STAT6 GOF patients display high expression of STAT6 target genes. (A) Expression of IL4Rα in naive and memory CD4⁺ cells is quantified as % positive cells in primary patient cells (n = 7, red) and healthy controls (n = 9, blue). Gating strategy for naive and memory and CD4⁺ is presented along with a dot plot for a fluoresence minus one (FMO) IL-4Rα sample to display IL-4Rα⁺ gating, as well as a representative dot plot for a patient and healthy control. (B) Expression of CD23 and IL4Ra in naive, non-class switched memory and memory B cells is quantified as % positive cells in primary patient cells (n = 7, red) and healthy controls (n = 9, blue). Gating strategy for B cell subsets is presented along with a dot plot for an FMO IL-4Rα sample to display IL-4Rα⁺ gating, as well as a representative dot plot for a patient and healthy control. Unpaired t test. **, P < 0.01; ***, P < 0.001.