Table 3. Median Absolute Change in Ki-67 and Progesterone Receptor (PgR) Expression After 4 to 6 Weeks of Treatment by Study Arm.
| Compliant participants | Median (IQR), % | P value, adjusteda | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Exemestane, 25 mg, QD (n = 52) | Exemestane, 25 mg, TIW (n = 53) | Exemestane, 25 mg, QW (n = 55) | |||||||||
| Biopsy | Surgery | Absolute change | Biopsy | Surgery | Absolute change | Biopsy | Surgery | Absolute change | QD vs TIW | QD vs QW | |
| Ki-67 | 13.0 (7 to 17) | 4.5 (2 to 8) | −7.5 (−11 to −3) | 13.0 (7 to 20) | 5.0 (2 to 12) | −5.0 (−10 to −1) | 12.0 (6 to 19) | 6.0 (3 to 13) | −4.0 (−8 to −1) | .31 | .06 |
| PgR | 65.0 (10 to 95) | 4.0 (0 to 40) | −17.0 (−67 to −4) | 70.0 (10 to 99) | 5.0 (0 to 70) | −9.0 (−50 to 0) | 70.0 (8 to 95) | 25.0 (0 to 80) | −7.0 (−25 to 0) | .44 | .06 |
| Adjacent tissue | Exemestane, 25 mg, QD (n = 28) | Exemestane, 25 mg, TIW (n = 22) | Exemestane, 25 mg, QW (n = 27) | QD vs TIW | QD vs QW | ||||||
| Ki-67 | 1.0 (1 to 2) | 1.5 (1 to 2) | 0.0 (0 to 1) | 1.0 (0 to 3) | 1.0 (1 to 2) | 0.0 (−0.5 to 0.5) | 1.0 (1 to 2) | 2.0 (1 to 3) | 0.0 (−1 to 1) | .30 | .88 |
Abbreviations: QD, once daily; QW, once weekly; TIW, 3 times weekly.
a
Adjusted for baseline levels, age, and body mass index. All P values were also adjusted for multiple testing.