Table 4.
Receiver operator characteristic analysis of spectral parameters in differentiating Ki-67 low expression status from high expression status
|
|
|
AUC (95%CI)
|
TV
|
YI
|
Sen (%)
|
Spe (%)
|
PPV (%)
|
NPV (%)
|
Acc (%)
|
| AP | Zeff | 0.759 (0.668, 0.836) | ≤ 8.27 | 0.67 | 85.92 | 81.08 | 92.96 | 37.84 | 71.30 |
| nZeff | 0.796 (0.707, 0.867) | ≤ 0.74 | 0.67 | 80.28 | 86.49 | 85.92 | 54.05 | 75.00 | |
| IC | 0.752 (0.660, 0.830) | > 1.63 | 0.60 | 78.87 | 81.08 | 88.73 | 21.62 | 65.74 | |
| nIC | 0.773 (0.683, 0.848) | > 0.16 | 0.61 | 74.65 | 86.49 | 81.69 | 48.65 | 70.37 | |
| VP | CT40 kev | 0.630 (0.531, 0.721) | ≤ 271.2 | 0.26 | 80.28 | 45.95 | 95.77 | 24.32 | 71.30 |
| CT70 kev | 0.631 (0.533, 0.722) | ≤ 138.8 | 0.31 | 92.96 | 37.84 | 94.37 | 32.43 | 73.15 | |
| CT100 kev | 0.662 (0.565, 0.750) | ≤ 89.3 | 0.28 | 81.69 | 45.95 | 87.32 | 32.43 | 68.52 | |
| Zeff | 0.777 (0.687, 0.851) | ≤ 8.75 | 0.73 | 88.73 | 83.78 | 92.96 | 29.73 | 74.07 | |
| nZeff | 0.835 (0.751, 0.899) | ≤ 0.83 | 0.68 | 78.87 | 89.19 | 85.92 | 51.35 | 74.07 | |
| IC | 0.747 (0.654, 0.826) | > 2.65 | 0.63 | 84.51 | 78.38 | 85.92 | 27.03 | 65.74 | |
| nIC | 0.805 (0.718, 0.875) | > 0.43 | 0.71 | 78.87 | 91.89 | 85.92 | 37.84 | 69.44 | |
| Multi-parameters | 0.967 (0.913, 0.992) | - | 0.88 | 95.77 | 91.89 | 97.18 | 86.49 | 93.52 | |
AUC: Area under the curve; TV: Threshold value; YI: Youden index; Sen: Sensitivity; Spe: Specificity; NPV: Negative predictive value; PPV: Positive predictive value; Acc: Accuracy; ZeffAP and ZeffVP: The effective atomic number in the arterial and venous phase; nZeffAP and nZeffVP: The normalized effective atomic number in the arterial and venus phase; ICAP and ICVP: The iodine concentration in the arterial and venous phase; nICAP and nICAP: The normalized iodine concentration in the arterial and venous phase; CT40 kev, CT70 kev and CT100 kev: The computed tomography attenuation values of at 40 kilo electron volt (kev), 70 kev and 100 kev respectively.