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Distributions of modulated NF-κB and IRF activity from primary screen. RAW Dual cells transcription factor activity for IRF (A), and NF-κB (B) 24 h after addition of modulator + agonist. Modulator (N = 3147) + agonist (N = 13) activity reported as a fold change compared to agonist alone activity. Inhibition and enhancement over multiple orders of magnitude is observed.
