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. 2023 Feb 16;9(3):393–404. doi: 10.1021/acscentsci.2c01349

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© 2023 The Authors. Published by American Chemical Society

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Extracted ion abundance for O-glycopeptides from FL-S or S1/S2 recombinant spike fractions. (A) Mass areas were normalized against their corresponding base peaks and multiplied by a factor of 10 000. All data analysis was performed in Thermo XCalibur software from extracted ion chromatograms and hand-curated. Highlighted T corresponds to Thr678, which was found to be modified by diverse O-glycans. Data are from one experiment. (B) Summary of VOC mutations within the FCS proximal region and their established impact on glycosylation and proteolysis.