Figure S1.

Target dose distribution under different LET objective weighting $w_{LET}$. Dose plots (a-h): the 1^st and 2^nd rows correspond to ICR and QN respectively; the 1^st, 2^nd, 3^rd and 4^th columns correspond to dose $d$ for $w_{LET}=1,0.2,0.01$, and 0 respectively. DVH of CTV plots (i-k) for $w_{LET}=1,0.2$, and 0.01 respectively. The display window for $d$ is [0%, 110%] of prescription dose, and iso-dose lines of 105% and 80% are highlighted in (a-h).