Fig. 2. ncRNA-mediated regulation of TIME. ncRNAs (miRNAs/lncRNAs/circRNAs) regulate the development, activation, recruitment, and cellular function of multiple cell types within TIME of HCC by diverse mechanisms.

CAF, cancer-associated fibroblast; circ, circular RNA; HCC, hepatocellular carcinoma; HSC, hepatic stellate cell; lnc, long noncoding RNA; MDSC, myeloid-derived suppressor cell; NK, natural killer; Treg, regulatory T cell; TIME, tumor immune microenvironment.