Fig. 6. Canonical loadings of set of variables.

Canonical loadings represent the correlation between a variable and its canonical variate and express the contribution of each variable to the overall correlation. (A) Loadings for blood variables, albumin has opposite correlation than bilirubin and INR, as expected. (B) Loadings for breath VOCs, limonene and 2-pentanone had a positive contribution. Dimethyl selenide (VOC4), which was downregulated in the breath of patients with cirrhosis, had a negative correlation. INR, international normalized ratio; VOCs, volatile organic compounds.