Table 2.
Baseline glucometabolic, lipid, and blood pressure parameters.
| Study | Fasting Plasma Glucose (mmol/L) (Mean ± SD) |
Fasting Serum Insulin pmol/L (Mean ± SD) |
HBA1c % | Free Testosterone pmol/L (Mean ± SD) |
Total Testosterone nmol/L (Mean ± SD) |
HOMA-IR (Mean ± SD) | Mean Total Cholesterol mmol/L (Mean ± SD) |
Systolic Blood Pressure mm of Hg (Mean ± SD) |
Diastolic Blood Pressure mm of Hg (Mean ± SD) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | TRT | Placebo | |
| Dhindsa (2015) [14] | 6.99 ± 0.44 | 6.60 ± 0.55 | 13.6 ± 3 rsul | 11.8 ± 2.2 | 6.8 ± 0.9 | 7 ±1.4 | 156.5 ± 45.11 | 145.74 ± 41.6 | 9 ± 2.9 | 8.3 ± 2.8 | 9 ± 2.9 | 8.3 ± 2.8 | 4.06 ± 0.98 | 4.03 ±0.95 | N/A | N/A | N/A | N/A |
| Gianatti (2014) [8] | 9.57 ± 3.78 | 9.11 ± 3.65 | N/A | N/A | 7.7 ± 1.3 | 7.5 ± 1.2 | 187.7 ± 57.0 | 181.2 ± 63.6 | 9.2 ± 3.1 | 8.9 ± 3.8 | 4.1 ± 2.0 | 3.7 ± 2.6 | 4.15± 0.90 | 4.08± 0.9 | 140.2 ± 15.9 | 137.1 ± 13.0 | 79.4 ± 9.4 | 77.5 ± 8.9 |
| Hackett (2014) [15] | 9.05 ± 3.18 | 8.49 ± 2.84 | 20.88 ± 22.83 | 18.17 ± 15.7 | N/A | N/A | 198 ± 49.3 | 202.4 ± 62.1 | 9.2± 2.6 | 9.5± 3.3 | 5.9± 3.8 | 4.9± 3.3 | 4.51± 1.17 | 4.55± 1.01 | 138.6± 17.30 | 136.7± 17.12 | 82.5± 10.23 | 81.6± 9.50 |
| Jones (2011) [16] | 7.9 ± 4.3 | 9.2 ± 3.4 | 12.80 ± 8.95 | 17.86 ± 24.72 | 6.43 ± 2.20 | 7.69 ± 2.77 | 177.57 ± 60.19 | 177.57 ± 60.19 | 10.1 ± 3.7 | 10.1 ± 3.7 | 5.50 ± 6.82 | 6.45 ± 8.75 | 4.7 ± 0.9 | 4.0 ± 1.0 | 115.83 ± 5.15 | 118.40 ± 9.97 | 82.00 ± 6.93 | 79.00 ± 3.16 |
| Gopal (2010) [17] | 7.9 ± 0.2 | 8.3 ± 0.2 | 19.03 ± 0.63 | 16.8 ± 0.87 | 7.5 ± 0.1 | 7.5 ± 0.1 | 200 ± 0.00 | 200 ± 0.00 | 10.5 ± 0.2 | 10.4 ±0.2 | 5.6 ± 0.3 | 6.1 ± 0.4 | N/A | N/A | 104.5± 2.6 | 143.5± 2.1 | 85.6± 0.9 | 85.0± 1.0 |
| Heufelder (2009) [18] | 7.83 ± 0.49 | 7.6 ± 0.43 | 13.68 ± 1.95 | 12.37 ± 1.87 | 7.28 ±0.19 | 7.28 ±0.19 | N/A | N/A | 8.63 ±0.51 | 8.63 ±0.51 | N/A | N/A | 5.11 ±0.17 | 4.95± 0.15 | 127.6± 2.8 | 131± 3.1 | 74± 1.4 | 74± 1.4 |
| Kapoor (2006) [19] | 8.0 ± 2.6 | 8.4 ± 2.8 | N/A | N/A | 10.4 ± 1.6 | 10.3 ± 1.6 | N/A | N/A | 9.56 ± 2.33 | 10.76 ± 3.0 | N/A | N/A | 5.50 ± 1.41 | 5.59 ± 1.49 | 122 ± 8 | 120 ± 8 | 80 ± 4 | 76 ± 6 |
| Boyanov (2003) [20] | N/A | N/A | N/A | N/A | 7.6 ± 1.3 | 7.5 ± 1.5 | 210 ± 124.5 | 175 ± 67.9 | 9.7 ± 4.4 | 8.9 ± 3.2 | N/A | N/A | 4.5 ± 1.1 | 4.1 ± 1.0 | 141.8± 16.1 | 139.4± 16.8 | 81.4 ± 10.4 | 78.2 ± 10.4 |
| Hackett (2018) [21] | 5.3 ± 0.8 | 4.9 ± 1.3 | N/A | N/A | 5.9 ± 0.2 | 5.9 ± 0.2 | N/A | N/A | 8.2 ± 2.1 | 9.6 ± 2.4 | N/A | N/A | 6.9 ± 1.2 | 6.4 ± 1.4 | 136.9 ± 13.5 | 129.8 ± 12.7 | 81.2 ± 8.9 | 84.7 ± 6.7 |
| Yassin (2019) [12] | 8.1 ± 3.7 | 8.7 ± 5.0 | N/A | N/A | 7.8 ± 2.4 | 7.9 ± 2.4 | 208 ± 142 | 223 ± 140 | 9.6 ± 2.7 | 9.9 ± 2.6 | N/A | N/A | 6.1 ± 1.2 | 5.9 ± 1.5 | N/A | N/A | N/A | N/A |
| Khirpun (2018) [22] | 10.06 ± 1.44 | 9.77 ± 1.40 | N/A | N/A | 8.12 ± 1.04 | 7.89 ± 0.77 | 208 ± 142 | 223 ± 140 | 7.24 ± 1.97 | 7.96 ± 1.34 | 11.45 ± 7.34 | 10.82 ± 6.52 | 5.31 ± 0.91 | 5.11 ± 0.85 | 134.64 ± 10.71 | 138.15 ± 13.24 | 77.50 ± 5.85 | 78.89 ± 5.25 |
| Groti (2020) [5] | 10.06 ± 1.44 | 9.60 ± 1.44 | 26.03 ± 15.86 | 24.89 ± 13.90 | 8.12 ± 1.04 | 7.89 ± 0.77 | N/A | N/A | 7.24 ± 1.97 | 7.96 ± 1.34 | 11.45 ± 7.34 | 10.70 ± 6.52 | 5.31 ± 0.91 | 5.31 ± 0.97 | 134.64 ± 10.71 | 138.15 ± 13.24 | 77.50 ± 5.85 | 78.89 ± 5.25 |
| Groti (2018) [23] | 10.06 ± 1.44 | 9.60 ± 1.44 | 26.03 ± 15.86 | 24.89 ± 13.90 | 8.12 ± 1.04 | 7.89 ± 0.77 | N/A | N/A | 7.24 ± 1.97 | 7.96 ± 1.34 | 11.45 ± 7.34 | 10.70 ± 6.52 | 5.31 ± 0.91 | 5.31 ± 0.97 | 134.64 ± 10.71 | 138.15 ± 13.24 | 77.50 ± 5.85 | 78.89 ± 5.25 |
| Wittert (2021) [24] | 6·1 ± 0·9 | 6·1 ± 0·9 | N/A | N/A | 5·7 ± 0·5 | 5·7 ± 0·5 | N/A | N/A | 13·4 ± 4·1 | 13·9 ± 4·6 | N/A | N/A | N/A | N/A | 138.52 ± 14.2 | 139.88 ± 14 | 85.45 ± 8.5 | 85.13 ± 8.3 |
| Haider (2020) [13] | 7.8 ± 1.2 | 6.3 ± 0.7 | 28.6 ± 4.0 | 24.9 ± 2.9 | Forest plot | Forest plot | N/A | N/A | 9.3 ± 1.7 | 9.8 ± 1.1 | 9.8 ± 2.0 | 7.1 ± 1.3 | 8.3 ± 1.1 | 7.1 ± 1.2 | 163.0 ± 13.3 | 145.6 ± 14.6 | 97.6 ± 10.8 | 84.8 ± 10.3 |
SD: standard deviation, HOMA-IR: homeostasis model of insulin resistance, HBA1c: glycated hemoglobin.