Table 2.
Differentially expressed circulating miRNAs with validated target genes during the partial remission phase.
| miRNAs | PR vs. Ctrl (FC) |
p-Value | PR vs. T1D dx (FC) |
p-Value | PR vs. Non-PR (FC) |
p-Value |
|---|---|---|---|---|---|---|
| hsa-miR-30d-5p | 1.777 | 0.019 | - | - | 3.208 | 0.001 |
| hsa-let-7b-5p | - | - | - | - | −1.019 | 0.005 |
| hsa-miR-106a-5p | - | - | - | - | 2.771 | 0.006 |
| hsa-miR-20b-5p | - | - | - | - | 2.842 | 0.006 |
| hsa-let-7c-5p | - | - | - | - | −2.587 | 0.009 |
| hsa-miR-25-5p | −1.921 | 0.019 | - | - | −2.722 | 0.014 |
| hsa-miR-320b | - | - | - | - | 2.477 | 0.020 |
| hsa-miR-30e-5p | - | - | - | - | 2.485 | 0.022 |
| hsa-miR-142-3p | - | - | - | - | 1.125 | 0.023 |
| hsa-miR-106b-5p | - | - | - | - | 2.361 | 0.030 |
| hsa-miR-144-3p | - | - | −1.027 | 0.006 | 1.064 | 0.032 |
| hsa-miR-18b-5p | - | - | - | - | 2.235 | 0.043 |
| hsa-miR-17-5p | - | - | - | - | 1.319 | 0.048 |
| hsa-miR-1277-3p | 2.126 | 0.008 | - | - | 2.162 | 0.049 |
| hsa-miR-101-5p | −1.935 | 0.015 | −2.910 | 0.002 | - | - |
| hsa-miR-4485-3p | - | - | −2.890 | 0.005 | - | - |
| hsa-miR-10b-5p | - | - | 2.697 | 0.005 | - | - |
| hsa-miR-1976 | −1.568 | 0.037 | −2.433 | 0.008 | - | - |
| hsa-miR-296-5p | −1.830 | 0.018 | −2.444 | 0.009 | - | - |
| hsa-miR-377-3p | −2.028 | 0.016 | −2.558 | 0.013 | - | - |
| hsa-miR-543 | −1.838 | 0.023 | −2.311 | 0.018 | - | - |
| hsa-miR-24-3p | - | - | 2.069 | 0.019 | - | - |
| hsa-miR-3611 | −2.293 | 0.002 | −2.108 | 0.019 | - | - |
| hsa-miR-4485-5p | −-2.883 | 0.005 | −2.846 | 0.020 | - | - |
| hsa-miR-154-5p | −2.556 | 0.001 | −2.256 | 0.020 | - | - |
| hsa-miR-223-3p | - | - | 1.311 | 0.021 | - | - |
| hsa-miR-324-3p | - | - | −2.244 | 0.022 | - | - |
| hsa-miR-1-3p | - | - | −2.263 | 0.029 | - | - |
| hsa-miR-4449 | - | - | −1.951 | 0.037 | - | - |
| hsa-miR-365a-3p | - | - | 2.059 | 0.039 | - | - |
| hsa-miR-365b-3p | - | - | 2.059 | 0.039 | - | - |
| hsa-miR-4446-3p | −2.194 | 0.009 | −2.025 | 0.043 | - | - |
| hsa-miR-132-3p | - | - | −1.943 | 0.045 | - | - |
Data analyzed by moderated t-test. Abbreviations: Ctrl, controls; FC; fold change; non-PR, non-partial remission; PR, partial remission; T1D dx, type 1 diabetes diagnosis.