Table 2.

Pharmacokinetics Comparison. Integrated Area, C_mean, C_max, and C_min (all in ng/mL) were calculated from average weekly T levels per group over the first 6 weeks of T administration.

Dosage	Cumulative Dosage	Integrated Area (ng/mL)	Cmean	Cmax	Cmin	Number of Mice
0.45 mg 1x/wk	2.7 mg	21.869	3.887	6.985	1.297	5
0.45 mg 2x/wk	5.4 mg	41.505	9.047	10.644	6.866	5
0.90 mg 1x/wk	5.4 mg	40.889	7.375	9.448	6.282	5
5mg60d pellet	5.0 mg	56.576	9.834	19.979	5.172	5
5mg90d pellet	5.0 mg	99.357	16.041	29.641	0.492	10
5mg21wk sesame oil silastic	5.0 mg	53.245	9.105	19.790	3.087	5
10 mg -short crystalline T	10.0 mg	16.118	2.877	3.622	2.647	10
10 mg - long crystalline T	10.0 mg	18.976	3.384	4.351	3.014	10

Blue shaded box refers to T enanthate administration groups and green shaded box indicates crystalline T administration. Cumulative dosage ranges between 2.7–5.4 mg for T enanthate groups and 10.0 mg for crystalline T groups. Integrated areas, indicating the body’s exposure to T, of T enanthate cohorts typically correspond to the cumulative dosage, except for 5mg-90 day release pellet that demonstrated high initial release and then fell to levels comparable to control mice during the 6 weeks of T treatment. C_mean indicates the average T levels over 6 weeks of treatment. C_min refers to the lowest average T level during 6 weeks of T administration while C_max refers to the highest average T level in each group. The last column indicates how many T-treated mice were used in each cohort.