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. 2023 Mar 24;20:12. doi: 10.1186/s12014-023-09400-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Combination of GFAP and FABP4 for discriminating gliomas (red circles) from meningiomas (blue dots) Anaplastic astrocytomas (red crossed diamonds) and anaplastic oligodendrogliomas (red double diamonds) are also shown. A: The vertical dashed line shows GFAP cut-ff at 100% specificity for gliomas and the horizontal dashed line shows FABP4 cut-off at 100% specificity for meningiomas. This model also aggregates the glioma cases by sub-type with glioblastomas having high GFAP, meningioma having low GFAP and high FABP4, while anaplastic astrocytomas and oligodendrogliomas display both low FABP4 and low GFAP [9, 10]. At 100% specificity (correct prediction of all 20 meningiomas) the sensitivity (correct prediction of gliomas) was 25/30 or 83%. B: Classification using logistic regression. We correctly classified 18/20 meningiomas (specificity of 90%) and 28/30 gliomas (sensitivity of 93%). The misclassified cases (two gliomas and two meningiomas) are circled