Table 2.
Time course of lipoprotein particle concentrations in the years before testinga
| Control | IFG | IGT | IFG + IGT | T2D | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <Δc/Δt > | ||||||||||
| [nM/y] | [%/y] | [nM/y] | [%/y] | [nM/y] | [%/y] | [nM/y] | [%/y] | [nM/y] | [%/y] | |
| HDL A | 103.66 | 0.61 | -17.89 | -0.10 | 178.85 | 1.06 | 23.00 | 0.13 | 83.22 | 0.46 |
| HDL B | 68.26 | 1.48 | 88.33 | 1.96 | -98.19 | -2.19 | 138.34 | 2.89 | 111.33 | 2.54 |
| HDL C | 35.04 | 1.46 | 42.71 | 1.88 | -38.69 | -1.68 | 68.26 | 3.02 | 46.36 | 2.22 |
| HDL D | 12.41 | 1.08 | 11.68 | 1.01 | -0.37 | -0.03 | 23.00 | 1.97 | 15.70 | 1.37 |
| Apo-A1NMR | 109.68 | 0.22 | 62.42 | 0.12 | 20.81 | 0.04 | 126.29 | 0.25 | 128.30 | 0.25 |
| LDL A | 5.11 | 1.10 | 5.84 | 1.30 | -4.38 | -0.95 | 9.13 | 2.02 | 4.75 | 1.13 |
| LDL B | 3.65 | 0.99 | 2.56 | 0.70 | -2.56 | -0.68 | 6.21 | 1.67 | 3.29 | 0.92 |
| LDL C | 4.38 | 1.33 | 1.83 | 0.57 | -1.83 | -0.56 | 5.11 | 1.57 | 1.83 | 0.59 |
| LDL D | 1.46 | 0.65 | 0.00 | 0.00 | -1.46 | -0.64 | 1.46 | 0.65 | 0.37 | 0.17 |
| LDL E | 1.83 | 1.03 | 0.00 | 0.00 | -2.92 | -1.56 | 2.56 | 1.33 | 1.10 | 0.58 |
| IDL | 0.37 | 0.43 | -0.37 | -0.43 | -1.46 | -1.69 | 0.37 | 0.41 | 0.00 | 0.00 |
| VLDL A | 0.00 | 0.00 | -0.37 | -0.79 | -1.10 | -2.28 | 0.73 | 1.48 | 0.37 | 0.75 |
| VLDL B | 0.00 | 0.00 | 0.00 | 0.00 | -0.37 | -3.40 | 0.00 | 0.00 | 0.00 | 0.00 |
| Apo-B100NMR | 2.10 | 0.12 | 1.19 | 0.07 | -2.01 | -0.12 | 3.19 | 0.19 | 1.46 | 0.09 |
| CM Re | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CM A | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CM B | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Apo-B48NMR | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
aData are taken from the reserve samples. Note that disorders of the glucose metabolism were newly diagnosed for all participants of this study and that values correspond to normal nutritional conditions. The particle concentrations c were linearly fitted as function of the time t before the oGTT. <Δc/Δt > is the mean slope of the line of best fit, either expressed in nM/year or %/year. The percents are related to the particle concentrations extrapolated to t = 0. Number of participants 595. The Apo-A1NMR concentrations were calculated from the HDL concentrations assuming 2 Apo-A1 molecules /HDL-particle, the Apo-B100NMR concentrations were calculated as the sum of VLDL, IDL and LDL particle concentrations assuming 1 Apo-B100 molecule/particle, the Apo-B48 concentrations were calculated as the sum of all chylomicron particle concentrations assuming 1 Apo-B48 molecule/particle (see Discussion)