. 2023 Mar 24;22:42. doi: 10.1186/s12944-023-01801-7

Table 3.

Comparison of lipoproteins concentrations obtained under fasting and non-fasting conditions^a

		Control	IFG	IGT	IFG + IGT	T2D
N_f		196	167	21	29	19
N_nf		251	193	26	68	57
Lipoprotein	Fasting state	c [nM]	c [nM]	c [nM]	c [nM]	c [nM]
HDL A	Fasting	16,628 ± 2839	16,885 ± 2939	16,725 ± 2658	17,107 ± 2445	17,408 ± 2776
(7 – 8.5 nm)	Non-fasting	16,963 ± 3320	17,362 ± 2777	16,799 ± 2420	17,285 ± 2251	18,014 ± 2454
(7 – 8.5 nm)	Δc_nf-f [%]	2	2.8	0.4	1	3.5
HDL B	Fasting	4688 ± 1451	4247 ± 1331	4586 ± 1692	4724 ± 1530	4218 ± 1123
(8.5 – 10 nm)	Non-fasting	4623 ± 1442	4501 ± 1267	4479 ± 1778	4779 ± 1493	4390 ± 1156
(8.5 – 10 nm)	Δc_nf-f [%]	-1.4	6	-2.3	1.2	4.1
HDL C	Fasting	2445 ± 903	2106 ± 695	2309 ± 1086	2259 ± 612	2004 ± 593
(10 – 13 nm)	Non-fasting	2407 ± 827	2270 ± 749	2300 ± 1049	2263 ± 614	2085 ± 565
(10 – 13 nm)	Δc_nf-f [%]	-1.6	7.8	-0.4	0.2	4.1
HDL D	Fasting	1159 ± 206	1111 ± 170	1184 ± 228	1174 ± 183	1125 ± 147
(13 – 16 nm)	Non-fasting	1154 ± 193	1158 ± 176	1193 ± 235	1170 ± 155	1149 ± 162
(13 – 16 nm)	Δc_nf-f [%]	-0.5	4.2	0.7	-0.3	2.1
HDL total	Fasting	24,921 ± 3488	24,349 ± 3423	24,805 ± 3272	25,265 ± 2840	24,754 ± 3003
(7 – 16 nm)	Non-fasting	25,147 ± 3874	25,290 ± 3234	24,771 ± 3104	25,498 ± 2947	25,638 ± 3128
(7 – 16 nm)	Δc_nf-f [%]	0.9	3.9	-0.1	0.9	3.6
Apo-A1_NMR^b	Fasting	49,842 ± 6976	48,698 ± 6845	49,611 ± 6543	50,529 ± 5679	49,508 ± 6006
	Non-fasting	50,294 ± 7749	50,581 ± 6468	49,543 ± 6207	50,996 ± 5893	51,276 ± 6255
	Δc_nf-f [%]	0.9	3.9	-0.1	0.9	3.6
LDL A	Fasting	469.2 ± 127.2	426.4 ± 97.6	469.6 ± 172.6	455.1 ± 81.2	395.1 ± 97.6
(16 – 19 nm)	Non-fasting	465.5 ± 118.5	449.9 ± 105.7	461.4 ± 174.8	452.0 ± 87.9	420.7 ± 86.3
(16 – 19 nm)	Δc_nf-f [%]	-0.8	5.5	-1.7	-0.7	6.5
LDL B	Fasting	370.0 ± 74.3	354.3 ± 61.0	375.2 ± 85.6	374.5 ± 59.8	339.1 ± 59.0
(19 – 21 nm)	Non-fasting	369.4 ± 72.2	367.3 ± 66.0	374.2 ± 89.8	371.1 ± 57.4	358.8 ± 59.1
(19 – 21 nm)	Δc_nf-f [%]	-0.2	3.7	-0.3	-0.9	5.8
LDL C	Fasting	328.5 ± 66.5	314.9 ± 56.4	331.2 ± 78.5	328.6 ± 54.5	296.2 ± 63.4
(21 – 22 nm)	Non-fasting	329.9 ± 70.1	323.0 ± 64.7	326.7 ± 82.9	324.6 ± 53.9	311.5 ± 55.9
(21 – 22 nm)	Δc_nf-f [%]	0.4	2.6	-1.4	-1.2	5.1
LDL D	Fasting	221.3 ± 48.7	216.9 ± 45.1	225.0 ± 54.2	229.0 ± 51.1	205.1 ± 53.7
(22 – 25 nm)	Non-fasting	223.6 ± 57.1	223.1 ± 47.1	227.5 ± 59.1	224.0 ± 47.1	219.2 ± 47.0
(22 – 25 nm)	Δc_nf-f [%]	1	2.8	1.1	-2.2	6.9
LDL E	Fasting	175.6 ± 41.9	180.3 ± 41.0	185.4 ± 35.7	196.6 ± 58.0	169.8 ± 44.1
(25 – 30 nm)	Non-fasting	177.6 ± 53.2	183.2 ± 46.1	187.6 ± 38.2	191.5 ± 45.3	188.8 ± 47.8
(25 – 30 nm)	Δc_nf-f [%]	1.1	1.6	1.2	-2.6	11.2
LDL total	Fasting	1564.7 ± 328.1	1492.9 ± 273.4	1586.4 ± 406.0	1583.7 ± 266.8	1405.2 ± 286.3
(16 – 30 nm)	Non-fasting	1566.0 ± 336.1	1546.5 ± 301.0	1577.2 ± 423.9	1563.1 ± 262.4	1498.8 ± 271.7
(16 – 30 nm)	Δc_nf-f [%]	0.1	3.6	-0.6	-1.3	6.7
IDL	Fasting	83.41 ± 20.95	84.43 ± 20.27	83.41 ± 19.31	91.8 ± 28.37	78.71 ± 23.38
(30 – 40 nm)	Non-fasting	84.87 ± 27.24	85.67 ± 21.48	86.58 ± 19.4	88.13 ± 21.97	86.57 ± 22.98
(30 – 40 nm)	Δc_nf-f [%]	1.8	1.5	3.8	-4	10
VLDL A	Fasting	42.93 ± 13.76	45.08 ± 13.79	45.22 ± 12.18	51.88 ± 23.09	43.17 ± 15.54
(40 – 60 nm)	Non-fasting	43.33 ± 17.74	45.98 ± 14.42	48.03 ± 11.93	49.4 ± 15.7	48.95 ± 16.87
(40 – 60 nm)	Δc_nf-f [%]	0.9	2	6.2	-4.8	13.4
VLDL B	Fasting	9.92 ± 3.22	10.32 ± 3.26	10.1 ± 3.03	12.28 ± 6.02	9.35 ± 3.23
(60 – 80 nm)	Non-fasting	10.06 ± 4.34	10.5 ± 3.42	10.74 ± 2.68	11.35 ± 3.61	11.19 ± 4.11
(60 – 80 nm)	Δc_nf-f [%]	1.4	1.7	6.3	-7.6	19.7
IDL and VLDL	Fasting	136.26 ± 37.08	139.83 ± 36.48	138.72 ± 33.32	155.95 ± 56.55	131.22 ± 40.77
(30 – 80 nm)	Non-fasting	138.27 ± 48.51	142.15 ± 38.65	145.35 ± 32.75	148.88 ± 40.54	146.71 ± 43.34
(30 – 80 nm)	Δc_nf-f [%]	1.5	1.7	4.8	-4.5	11.8
Apo-B100_NMR^b	Fasting	1700.9 ± 352.0	1632.7 ± 300.9	1725.1 ± 431.3	1739.6 ± 310.7	1536.4 ± 318.3
	Non-fasting	1704.2 ± 372.0	1688.6 ± 329.4	1722.6 ± 449.1	1712.0 ± 294.3	1645.5 ± 306.3
	Δc_nf-f [%]	0.2	3.4	-0.1	-1.6	7.1
CM Re	Fasting	0.66 ± 0.28	0.7 ± 0.28	0.7 ± 0.25	0.86 ± 0.52	0.68 ± 0.33
(80 – 100 nm)	Non-fasting	0.66 ± 0.35	0.73 ± 0.28	0.77 ± 0.23	0.8 ± 0.33	0.78 ± 0.34
(80 – 100 nm)	Δc_nf-f [%]	0	4.3	10	-7	14.7
CM A	Fasting	0.42 ± 0.17	0.44 ± 0.18	0.43 ± 0.16	0.56 ± 0.35	0.4 ± 0.17
(100 – 150 nm)	Non-fasting	0.42 ± 0.23	0.45 ± 0.18	0.47 ± 0.14	0.51 ± 0.2	0.5 ± 0.23
(100 – 150 nm)	Δc_nf-f [%]	0	2.3	9.3	-8.9	25
CM B	Fasting	0.075 ± 0.039	0.079 ± 0.04	0.076 ± 0.041	0.109 ± 0.083	0.066 ± 0.041
(> 150 nm)	Non-fasting	0.073 ± 0.051	0.082 ± 0.038	0.0810 ± 0.030	0.095 ± 0.046	0.088 ± 0.048
(> 150 nm)	Δc_nf-f [%]	-2.7	3.8	6.6	-12.8	33.3
CM total	Fasting	1.15 ± 0.48	1.22 ± 0.49	1.21 ± 0.45	1.53 ± 0.94	1.14 ± 0.54
(80 – 430 nm)	Non-fasting	1.15 ± 0.62	1.26 ± 0.49	1.32 ± 0.38	1.41 ± 0.57	1.37 ± 0.61
(80 – 430 nm)	Δc_nf-f [%]	0	3.3	9.1	-7.8	20.2
Apo-B48_NMR^b	Fasting	1.15 ± 0.48	1.22 ± 0.49	1.21 ± 0.45	1.53 ± 0.94	1.14 ± 0.54
	Non-fasting	1.15 ± 0.62	1.26 ± 0.49	1.32 ± 0.38	1.41 ± 0.57	1.37 ± 0.61
	Δc_nf-f [%]	0	3.3	9.1	-7.8	20.2

^aFor lipoprotein nomenclature see Methods. The values given are the mean ± the standard deviation. The fasting values are from the spectra taken before the oGTT, the non-fasting values were extrapolated to time t = 0 from the spectra of reserve samples of the blood donors. Δc_nf-f [%], relative particle concentrations c under non-fasting conditions minus those under fasting conditions. Number of participants analysed under fasting conditions (N_f) and non-fasting conditions (N_nf) 432 and 595, respectively. First column, values in bracket represent the diameters assumed for different subclasses

^bThe NMR derived apolipoprotein concentrations were calculated as described in Table 2