Table 4.
Change of lipoprotein particle diameters and volumes after fastinga
| Fasting state | Control | IFG | IGT | IFG + IGT | T2D | |
|---|---|---|---|---|---|---|
| Nf | 196 | 167 | 21 | 29 | 19 | |
| Nnf | 251 | 193 | 26 | 68 | 57 | |
| Lipoprotein | ||||||
| HDL total | Fasting | |||||
| (7 – 16 nm) | < d > [nm] | 8.62 | 8.55 | 8.61 | 8.59 | 8.52 |
| < V > [nm3] | 721 | 701 | 717 | 711 | 693 | |
| Non-Fasting | ||||||
| < d > [nm] | 8.60 | 8.57 | 8.60 | 8.58 | 8.53 | |
| < V > [nm3] | 715 | 707 | 716 | 709 | 694 | |
| Δdnf-f [%] | -0.26 | 0.23 | -0.05 | -0.06 | 0.06 | |
| ΔVnf-f [%] | -0.87 | 0.75 | -0.10 | -0.25 | 0.18 | |
| Δcnf-f [%] | 0.9 | 3.9 | -0.1 | 0.9 | 3.6 | |
| LDL total | Fasting | |||||
| (16 – 30 nm) | < d > [nm] | 20.0 | 20.2 | 20.1 | 20.2 | 20.2 |
| < V > [nm3] | 9.07E + 3 | 9.27E + 3 | 9.14E + 3 | 9.29E + 3 | 9.28E + 3 | |
| Non-Fasting | ||||||
| < d > [nm] | 20.0 | 20.1 | 20.1 | 20.1 | 20.2 | |
| < V > [nm3] | 9.10E + 3 | 9.20E + 3 | 9.19E + 3 | 9.25E + 3 | 9.35E + 3 | |
| Δdnf-f [%] | 0.16 | -0.27 | 0.20 | -0.13 | 0.20 | |
| ΔVnf-f [%] | 0.31 | -0.72 | 0.57 | -0.39 | 0.74 | |
| Δcnf-f [%] | 0.1 | 3.6 | -0.6 | -1.30 | 6.7 | |
| IDL and VLDL | Fasting | |||||
| (30 – 80 nm) | < d > [nm] | 42.3 | 42.4 | 42.4 | 42.7 | 42.4 |
| < V > [nm3] | 9.06E + 4 | 9.15E + 4 | 9.15E + 4 | 9.38E + 4 | 9.12E + 4 | |
| Non-Fasting | ||||||
| < d > [nm] | 42.2 | 42.4 | 42.5 | 42.6 | 42.7 | |
| < V > [nm3] | 9.05E + 4 | 9.16E + 4 | 9.22E + 4 | 9.30E + 4 | 9.32E + 4 | |
| Δdnf-f [%] | -0.06 | 0.04 | 0.25 | -0.23 | 0.62 | |
| ΔVnf-f [%] | -0.14 | 0.11 | 0.76 | -0.87 | 2.18 | |
| Δcnf-f [%] | 1.5 | 1.7 | 4.8 | -4.5 | 11.8 | |
| CM total | Fasting | |||||
| (80 – 430 nm) | < d > [nm] | 121 | 121 | 120 | 123 | 119 |
| < V > [nm3] | 4.55E + 6 | 4.54E + 6 | 4.44E + 6 | 4.88E + 6 | 4.24E + 6 | |
| Non-Fasting | ||||||
| < d > [nm] | 121 | 121 | 120 | 122 | 121 | |
| < V > [nm3] | 4.47E + 6 | 4.54E + 6 | 4.35E + 6 | 4.69E + 6 | 4.52E + 6 | |
| Δdnf-f [%] | -0.36 | -0.09 | -0.42 | -0.94 | 1.72 | |
| ΔVnf-f [%] | -1.84 | 0.08 | -2.01 | -3.99 | 6.75 | |
| Δcnf-f [%] | 0.0 | 3.3 | 9.1 | -7.8 | 20.2 | |
aThe fasting values are from the spectra taken before the oGTT, the non-fasting vales were extrapolated to time t = 0 from the spectra of reserve samples of the blood donors. < d > , average particle diameter and < V > average volume calculated with the diameters given in Methods assuming a spherical shape.. Δdnf-f, ΔVnf-f, and Δcnf-f, relative differences (in %) of particle diameters, volumes, and concentrations under non-fasting conditions minus those under fasting conditions. Nf and Nnf , number of participants analysed under fasting or non-fasting conditions, respectively. Differences of mean values between fasting and non-fasting subjects with an error probability ≤ 0.05 are presented in bold letters