Figure 4:

Stratified/interaction model for latency to first growth spurt. Results from 100 repeated holdouts testing the association between the phthalate index and latency to first growth spurt (in PMA weeks), controlling for sex, SGA, NICU morbidity score, and year of birth, and including stratified weights and an interaction between the mixture and sex (N=101; training n~40, validation n~61). A. shows the distribution of WQS and WQS*sex estimates where data points represent the estimate for each holdout and the closed diamond shows the mean effect estimate and the boxplot shows the 25^th, 50^th, and 75^th percentiles and the whiskers show the 2.5^th and 97.5^th percentiles. B. shows the relative weight of each phthalate metabolite, using the average weight from the 100 holdouts divided by the sum of the averages, stratified by sex.