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. 2023 Mar 20;15(1):2190304. doi: 10.1080/19490976.2023.2190304

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — Administration of LGG improves the Th17/Treg balance in gut. (a) Thymus and spleen index (organ weight/body weight). (n=(12). Frequencies of Th 17 cells and T reg in MLN. (c-d) Th17(CD4+IL-17A+), Treg(CD4+CD25+FOXP3+). (n = 3). (e) the IL-17+/FOXP3+ % value represents the difference of Th17/Treg ratio between groups. (n = 3). (f-i) Colonic pro-inflammatory cytokines concentration. IL-17, TNF-α; colonic anti-inflammatory cytokine concentration. IL-10, TGF-β. (n = 6). Data are expressed as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Dunnett multiple comparisons test). Th 17, T helper cell 17; T reg, Regulatory T cell; MLN, mesenteric lymph nodes; LGG, Lactobacillus rhamnosus.