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. 2023 Mar 20;15(1):2190304. doi: 10.1080/19490976.2023.2190304

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Administration of LGG improves the Th 17/T reg balance in BM. (a) Representative pictures of immunohistochemistry staining of RORγt and FOXP3 in femur tissue of the three groups (scale bar, 100 µm). (b) Measurements included IOD/area analysis, with each sample analyzed in three different fields of view. (n = 3). (c) RORγt/FOXP3 was used to measure Th17/Treg in BM. (d-g) Pro-inflammatory cytokines, IL-17 and TNF-α, and anti-inflammatory cytokines concentration, IL-10 and TGF-β, in BM. (n = 6). (h) Expression of osteoclast cytokine RANKL in BM. (n = 6). (i-j) Analysis of the correlation between the bone and Th17/Treg. Heat map analysis of bone indexes and Th17/Treg, and cluster analysis among samples in groups. Matrix analysis for correlation analysis of all samples. Data are expressed as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Dunnett multiple comparisons test). Th 17, T helper cell 17; T reg, Regulatory T cell; IOD, integral optical density.