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. 2023 Mar 20;15(1):2188874. doi: 10.1080/19490976.2023.2188874

Figure 6.

Figure 6.

CGRP, but not substance P production by DRG neurons is higher in GF females after GPCR activation. (a) SPproduction in DRG neurons cultured ex vivo from SPF and GF mice of both sexes in response to vehicle (HBSS), capsaicin (1.25 μM) or GPCR agonists (30 μM). Data are expressed as box plots (10–90%ile) with n = 3 independent experiments of 1–4 wells per condition for SPF male/SPF female mice and GF male/GF female mice. (b) CGRP production in DRG neurons cultured ex vivo from SPF and GF both sexes in response to vehicle (HBSS), capsaicin (1.25 μM) and GPCR agonists (30 μM). Data are expressed box plots (10–90%ile); n = 4 independent experiments of 2-wells per condition for SPF male; n = 3 independent experiments (n = 2–4) for SPF female, GF male and GF female mice. Statistical analysis was performed using Kruskal-Wallis followed by Dunn’s post hoc test.