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. Author manuscript; available in PMC: 2023 Aug 7.
Published in final edited form as: Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372

Fig. 7. Model for XIAP and USP47 in regulating Gro/TLE ubiquitylation in the Wnt pathway.

Fig. 7.

(A) Upon Wnt signaling, XIAP ubiquitylates Gro/TLE, which promotes Gro/TLE dissociation from TCF to allow binding of β-catenin to TCF. (B) USP47 deubiquitylates Gro/TLE, thereby allowing it to displace β-catenin and rebind to TCF, setting up a cycle of β-catenin binding to and dissociation from TCF.