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Binding of CQ and HCQ to the PAD 4 enzyme. (a and b) Predicted binding sites of CQ (a) and HCQ (b) through computational docking studies (1 WDA.pdb). CQ is predicted to bind to amino acid residue Arg639 and HCQ to Trp347, Ser468, and Glu580 in PAD4. (c–e) SPR analysis determining binding potential of CQ (c) and HCQ (d) to PAD4 with KD values at 54.1 µM, and 88.1 µM respectively (e).
