Fig. 7. Proposed hypothetical model for differential immune responses between uncomplicated and SD patients.

Schematic of the kinetics and magnitude of cell subtype abundance and protein marker expression during acute D and SD infections. Most prominent differences in innate and adaptive immune responses are shown. Prominent differences in immune responses between adults and children and SDp with DHF/DSS and OI are also depicted. Black titles depict findings detected in the current study; gray titles depict predicted phenotypes that require further functional validation.