Table 2. The hypervariable region (HVR) sequence and PTMs of the G-proteins in this study.

Sub family	G-protein	HVR sequence	Modified cysteine	PTMs	Cluster of adjacent K and R	References
RAS	KRAS4b	166HKEKMSKDGKKKKKKSKTK CVIM188	C185	F	yes	[24]
	KRAS4a	166HKLRKLNPPDESGPGCMSCKCVLS189	C186 C180	F & P	–	[24]
	HRAS	166HKLRKLNPPDESGPGCMSC K CVLS189	C181 C184 C186	F & P	no	[24]
	NRAS	166YRMKKLNSSDDGTQGCMGLPCVVM189	C181 C186	F & P	no	[24]
Rho	RHOA	171FEMATRAALQARRGKKKSGCLVL193	C190	F or GG	yes	[43, 44]
	RAC1	171EAIRAVLCPPPVKKRKRK CLLL192	C189	GG	yes	[44]
	CDC42	171EAILAALEPPEPKKSRR CVLL191	C188	GG	yes	[44]
Rab	RAB5A	191ANSARGRGVDLTEPTQPTRNQCCSN215	C212 C213	2 GG	no	[45]

Abbreviations: F: farnesylation; P: palmitoylation; GG: geranylgeranylation.