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| Compound | 48 h EC50 (μM) | |||
|---|---|---|---|---|
| NCI-H1299 | A549 | MDA-MB-468 | MDA-MB-231 | |
| NSL-YHJ-2-27 | 5.3* | 2.2* | 2.2* | 4.4 |
| NSL-YHJ-2-62 | >50* | >50* | >50* | >50 |
The potency of NSL-YHJ-2-27 is apparent in all cell lines, however, the non-polyisoprenylated compound, NSL-YHJ-2-62 did not show any effect on cell viability. *These values have previously been reported as part of a broader study of structure-activity relationships of the PCAIs [52].
