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Conformational changes of Spike_TMPRSS2 binding interface. A The S protein monomer structures of the WT_TMPRSS2, Delta_TMPRSS2, Mu_TMPRSS2, and Omicron_TMPRSS2 systems were superimposed using the S2 fragment with almost unchanged conformation as a reference; B the binding site of spike with TMPRSS2 is divided into two regions that are presented in a/b panels
