Table:
Demographics, clinical measures, and motion parametersa
| FEP (n= 78) | HC (n= 64) | t/X2/F | p value | |
|---|---|---|---|---|
| Demographic variables | ||||
| Gender (% male) | 64.1 | 64.1 | 0.00 | 1.0 |
| Age | 23.71 (5.96) | 24.27 (5.87) | 0.56 | .58 |
| Parental Occupationb | 5.46 (4.62) | 4.23 (3.99) | 16.27 | .43 |
| Clinical variables | ||||
| Diagnosis | ||||
| Schizophrenia | 41 | |||
| Schizoaffective Disorder | 15 | |||
| Schizophreniform Disorder | 3 | |||
| Brief Psychotic Disorder | 2 | |||
| Bipolar Disorder with psychosis | 3 | |||
| Major Depression with psychosis | 2 | |||
| Unspecified Psychosis | 12 | |||
| Duration of untreated psychosis [in months; median, mean, (SD)]c | 7; 23.50 (40.59) | |||
| UDS +cannabis (%) | 32.1 | |||
| BPRSd | ||||
| Total | 49.75 (11.47) | |||
| Positive | 15.62 (4.10) | |||
| Negative | 5.71 (3.10) | |||
| RBANSe | ||||
| Total index | 73.49 (15.21) | 92.47 (10.96) | 8.11 | < .01 |
| Immediate memory | 80.94 (16.68) | 101.05 (15.99) | 6.87 | < .01 |
| Visuospatial | 74.25 (11.62) | 82.33 (13.02) | 2.95 | < .01 |
| Language | 80.94 (16.68) | 97.50 (14.91) | 4.84 | < .01 |
| Attention span | 79.81 (16.72) | 101.57 (15.95) | 7.43 | < .01 |
| Delayed memory | 76.25 (15.69) | 90.98 (8.78) | 6.62 | < .01 |
| Scan quality data | ||||
| DWIf | ||||
| RMS absolute motion (mm) | 0.39 (0.24) | 0.32 (0.20) | −1.90 | .06 |
| RMS relative motion (mm) | 0.007 (0.006) | 0.005 (0.004) | −1.62 | .10 |
FEP, first episode psychosis patient; HC, healthy control; UDS, urine drug screen; DWI, diffusion weighted image; DWI, diffusion weighted imaging; RMS, root mean square of the six motion parameters (translations and rotations)
Mean (SD) unless indicated otherwise
Ranks determined from Diagnostic Interview for Genetic Studies (1 – 18 scale); higher rank (lower numerical value) corresponds to higher socioeconomic status
data not available for one subject
Brief Psychiatric Rating Scale (1 – 7 scale); positive (conceptual disorganization, hallucinatory behavior, suspiciousness and unusual thought content); negative (emotional withdrawal, motor retardation, and blunted affect); data available for 77 patients
Repeatable Battery for the Assessment of Neuropsychological Status; data available for 58 HC and 68 FEP
data available for 59 HC and 61 FEP