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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Pharmacoepidemiol Drug Saf. 2022 Nov 14;32(4):426–434. doi: 10.1002/pds.5565

TABLE 4.

Parameter estimates of cox proportional hazards model by varying levels of restriction by continuity ratio

Hazard ratio 95% confidence interval Standardized differencea
PALOMA-2 trial result 0.64 (0.52, 0.78) -
Following multiple imputation and restriction to top 25th percentile CR 0.63 (0.52, 0.77) −0.01
Following multiple imputation and restriction to top 50th percentile CR 0.61 (0.54, 0.69) −0.05
Following multiple imputation and restriction to top 75th percentile CR 0.60 (0.53, 0.68) −0.07
Following multiple imputation (not restricted by CR) 0.62 (0.56, 0.68) −0.05
a

Comparing PALOMA-2 trial result (top row) to real-world evidence analyses (remaining rows).