Table 4:

Longitudinal Analyses and Least Square Means and Pairwise Comparisons of 3 Groups Defined by Treatment Patterns for Visual Acuity and Central Subfield Thickness Post-baseline Outcomes

Outcome	1. Treated Continuously			2. Discontinued Treatment Early			3. Treated Intermittently			P-value 1 vs 2	P-value 1 vs 3	P-value 2 vs 3
	LS Mean	Lower 95% CI	Upper 95% CI	LS Mean	Lower 95% CI	Upper 95% CI	LS Mean	Lower 95% CL	Upper 95% CL
VALS	68.6	65.8	71.4	73.2	67.8	78.6	67.4	63.4	71.5	0.14	0.65	0.10
Change from baseline in VALS	18.6	15.6	21.5	23.4	17.7	29.1	17.2	13.0	21.5	0.14	0.61	0.09
CST	300	285	315	257	227	287	303	281	325	0.01	0.81	0.02
Change from baseline in CST	−397	−415	−380	−443	−477	−409	−394	−419	−369	0.02	0.81	0.02

Abbreviations: LS=Least Square; CL=Confidence Limits; VALS-Visual Acuity Letter Score; CST=Central Subfield Thickness.